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. 2020 Sep 10;295(48):16251–16266. doi: 10.1074/jbc.RA119.012330

Figure 5.

Figure 5.

GA increases ADAM10 and decreases BACE1 proteins, and elevates abundance of the ADAM10 activating enzyme furin in APP/PS1 brains. A, Western blots are shown using C-terminal ADAM10 pAb (ADAM10), C-terminal BACE1 pAb (BACE1), or furin pAb (furin). Actin is included as an internal loading control, and densitometry results are shown for ratios of precursor ADAM10 (pADAM10) or mature ADAM10 (mADAM10) to actin (B and C), for furin to actin (D), or for BACE1 to actin (E). Data for A-E were obtained from APP/PS1 mice that received vehicle (APP/PS1-V, n = 12) or GA (APP/PS1-GA, n = 12) for 6 months commencing at 12 months of age. Data for B-E are presented as mean ± S.D. Statistical comparisons for B-E are between-groups for each protein. **, p < 0.01; ***, p < 0.001 for APP/PS1-GA versus APP/PS1-V mice.