Figure 8.

GA therapy stabilizes brain oxidative stress in APP/PS1 mice. A, Western blots are shown using anti-Cu/Zn SOD pAb (SOD1) or anti-GPx1 pAb (GPx1), with actin as an internal loading control. Densitometry data are shown below each lane for SOD1 (B) or GPx1 (two bands; upper and lower) as ratios to actin (C). Data for B and C were obtained from APP/PS1 mice treated with vehicle (APP/PS1-V, n = 12) or GA (APP/PS1-GA, n = 12), and also for WT littermates that received vehicle (WT-V, n = 12) or GA (WT-GA, n = 12) for 6 months commencing at 12 months of age (mouse age at sacrifice = 18 months). Data for B and C are presented as mean ± S.D. Statistical comparisons for B and C are between-groups for each band. ***, p < 0.001 for APP/PS1-V versus the other treated mice.