Table 3.
Predicted binding of the beta-lactoglobulin derived peptides on the protein surface from ACE from Homo sapiens.
| Sequence | Active amino acids | P * | Potentially bound amino acids on the ACE enzyme (PDB: 2YDM) |
|---|---|---|---|
| ALPMHIR | Leu-2, Pro-3, Met-4, His-5, Ile-6, Arg-7 | 4.47e-05 | GLN281, HIS353, ALA354, SER355, HIS383, GLU384, HIS387, GLU411, ASP415, PHE457, LYS511, HIS513, TYR520, TYR523, SER526 |
| IPAVFK | Ile-1, Pro-2, Ala-3, Val-4, Phe-5 | 0.0001 | GLN281, HIS353, ALA354, HIS383, GLU384, HIS387, GLU411, ASP415, PHE457, LYS511, HIS513, TYR520, TYR523, SER526 |
| GLDIQK | Gly-1, Leu-2, Asp-3, Ile-4, Gln-5 | 0.0014 | GLN281, HIS353, ALA354, HIS383, GLU384, HIS387, PHE391, GLU411, PHE457, LYS511, HIS513, TYR520, TYR523, PHE527 |
| IIAEK | Ile-1, Ile-2, Ala-3, Lys-5 | 0.0009 | TRP279, GLN281, HIS353, ALA354, HIS383, HIS387, PHE391, GLU411, PHE457, PHE460, LYS511, HIS513, TYR520, TYR523 |
| TPEVDK | Thr-1, Pro-2, Glu-3, Val-4, Lys-6 | 0.0009 | GLN281, HIS353, HIS383, GLU384, HIS387, HIS410, GLU411, ALA412, ILE413, ASP415, PHE457, LYS511, HIS513, TYR520, TYR523, SER526, PHE527, GLN530 |
| EALEK | Glu-1, Ala-2, Leu-3, Lys-5 | 0.0091 | GLN281, HIS353, ALA354, HIS383, GLU384, HIS387, GLU411, PHE457, LYS511, HIS513, TYR520, TYR523 |
| IPP | Ile-1, Pro-2, Pro-3 | 9.736e-07 | GLN281, HIS353, ALA354, HIS383, GLU384, GLU411, PHE457, LYS511, HIS513, TYR520, TYR523 |
*: P value presents the statistical significance. ACE inhibitor IPP peptide was used as positive control (Watanabe et al., 2015).