Table 2.
Comparison of obstetrical, maternal and fetal outcomes between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected and non-infected pregnant women admitted for delivery.
| SARS-CoV-2 Infected Pregnant women |
Non infected Pregnant women | Relative Risks [95 %CI] | P value | |
|---|---|---|---|---|
| Outcomes of pregnancy | n = 137 | n = 370 (5 twin pregnancies) | ||
| Alive neonates > 25wg | 127 (92.7 %) | 364 (98.4 %) | 0.9 [0.9–1.0] | 0.0012 |
| Extremely preterm infants (22−23 + 6WG) (live births followed by a neonatal death) |
0 (0.0 %) | 6 (1.6 %) | 0.17 | |
| Intrauterine fetal death (19–35 W G) | 7 (5.1 %) | 4 (1.1 %) | 4.7 [1.4–15.9] | 0.0057 |
| Termination of pregnancy for fetal abnormalities | 3 (2.2 %) | 1 (0.3 %) | 0.06 | |
| Obstetric Outcomes, pregnancy ≥25WG | n = 127 | n = 359 (5 twin pregnancies) | ||
| Meconium-stained amniotic Fluid | 8 (6.3 %) | 30 (8.4 %) | 0.58 | |
| Fever during labor | 7 (5.5 %) | 9 (2.5 %) | 0.17 | |
| Uterine hyperkinesia / Hypertonia | 4 (3.1 %) | 15 (4.1 %) | 0.79 | |
| Abnormal fetal heart rate patterns | 23 (18.1 %) | 53 (14.8 %) | 0.45 | |
| Spontaneous preterm delivery <37 + 0 weeks | 11 (8.7 %) | 36 (10.0 %) | 0.78 | |
| Spontaneous preterm delivery <34 + 0 weeks | 1 (0.8 %) | 9 (2.6 %) | 0.4 | |
| Medically indicated preterm birth < 34 + 0 weeks | 0 (0.0 %) | 3 (0.8 %) | 0.57 | |
| Normal vaginal delivery | 101 (79.5 %) | 271 (75.4 %) | 0.42 | |
| Operative vaginal delivery | 7 (5.5 %) | 25 (7.0 %) | 0.71 | |
| Cesarean delivery before labor | 6 (4.7 %) | 18 (5.0 %) | 1 | |
| Cesarean delivery during labor | 13 (10.2 %) | 44 (12.3 %) | 0.65 | |
| Postpartum hemorrhage > 500 cc | 18 (14.2 %) | 26 (7.2 %) | 2.0 [1.1–3.4] | 0.0193 |
| Transfusion after hemorrhage | 7 (5.5 %) | 4 (1.1 %) | 4.9 [1.5–16.6] | 0.004 |
| Readmission | 4 (3.1 %) | 0 (0.0 %) | 0.004 | |
| Maternal complications (n = 137) | n = 137 | n = 370 (5 twin pregnancies) | ||
| Intensive care unit admission | 5 (3.6 %) | 3 (0.8 %) | 4.5 [1.1−18.6] | 0.0227 |
| Intensive care unit admission directly related to COVID 19 | 3 (2.2 %) | – | – | – |
| Oxygen support (nasal or non-invasive ventilation) related to COVID 19 | 3 (2.2 %) | – | – | – |
| Re hospitalization related to COVID 19 | 4 (2.9 %) | – | – | – |
| Endotracheal intubation for complication of COVID 19 | 0 (0.0 %) | – | – | – |
| Maternal death | 0 (0.0 %) | 0 (0.0 %) | – | – |
Risk Differences with 95 % confidence intervals are presented. Twin pregnancies were tested as effect-modifier and did not change the crude analysis reported.
COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; CI, confidence intervals; WG, weeks of gestation.