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. 2020 Nov 16;10:580750. doi: 10.3389/fonc.2020.580750

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Copyright © 2020 Curtin, Whitmire, Rickertsen, Mazza, Canoll, Johnston, Mrugala, Swanson and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cystic GBM survival benefit is driven by males. Overall survival comparisons between cystic and noncystic patients, both among all patients (top row) and current SOC patients (bottom row), separated into females (left column) and males (right column). Cystic GBM males had improved survival compared to noncystic GBM males among the entire cohort and they tended to have better outcomes among the current SOC patients. Among females, cystic GBM did not have significantly longer overall survival compared to noncystic GBM.