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. 2020 Nov 11;12:587989. doi: 10.3389/fnagi.2020.587989

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Copyright © 2020 Villar-Vesga, Henao-Restrepo, Voshart, Aguillon, Villegas, Castaño, Arias-Londoño, Zuhorn, Ribovski, Barazzuol, Cardona-Gómez and Posada-Duque.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The concentration and number of EVs are increased in the plasma of AD patients. (A) Mean size of EVs as measured by NTA from CNT (black), SAD (orange), and FAD (red) patients. (B) D10, (C) D50, and (D) D90 parameters obtained by NTA. (E) Representative contour plot of a control sample EV population and reference beads of different sizes. (F) Concentration of EVs/mL as measured by flow cytometry in the entire region and (G) in the different size intervals: MVs, 0.1–1; apoptotic bodies, 1–6. For (A–D), the representative data from CNT, n = 6; SAD, n = 5; FAD, n = 6. For panels (E–G), representative data from CNT, n = 6; SAD, n = 6; FAD, n = 6. Data are plotted as means and SEM. One-way ANOVA, Tukey’s multiple comparison test. * indicates p < 0.05; *** indicates p < 0.001.