Table 2.

Pharmacokinetic (PK) parameters of hepatitis B immunoglobulin in liver transplantation (LT) adults as a function of hepatitis virus replication status

PK parameters	Period (days)	Nn	Rn	Rr
Clearance (mL/h)	1–2	70	134	3260
	3–7	46	64	450
	8–30	14	14	24
	>30	7	7	13
Half-life (h)	1–2	59	27	0.7
	3–7	84	57	5
	8–30	266	270	123
	>30	446	545	204

The Nn group in which patients were non-replicators at the time of lamivudine initiation and at the time of LT

The Rn group in which patients were replicators at the time of lamivudine initiation but non-replicators at the time of or within 2 weeks prior to LT

The Rr group in which patients were replicators at both occasions