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. 2020 Dec 1;281:312–320. doi: 10.1016/j.jad.2020.11.118

Table 3.

Risk factors of depression, anxiety, and insomnia in the cohort identified by the multivariate analysis.

Characteristic Depression
Anxiety
Insomnia
Severe cases/ total cases (%) OR (95% CI) p Severe cases/ total cases (%) OR (95% CI) p Severe cases/ total cases (%) OR (95% CI) p
Stage of the COVID-19 epidemic in China
Remission 1132/4725(24.0) 1.22(1.03, 1.44) 0.02 897/4725(19.0) 1.22(1.02, 1.48) 0.033 452/4725(9.6)
Outbreak 280/951(29.4) 1 202/951(21.2) 1 112/951(11.8)
Gender
Females 337/1626(20.7) 1.61(1.39, 1.87) <0.001 284/1626(17.5) 1.35(1.15, 1.57) <0.001 172/1626(10.0)
Males 1075/4050(26.5) 1 815/4050(20.1) 1 402/4050(9.9)
Age groups
< 25 years old 407/1371(29.7) 2.09(1.66, 2.63) <0.001 296/1371(21.6) 1.86(1.48, 2.34) <0.001 157/1371(11.5) 1.58(1.17, 2.14) 0.003
25–45 years old 830/3307(25.1) 1.94(1.59, 2.37) <0.001 646/3307(19.5) 1.63(1.33, 2.01) <0.001 307/3307(9.3) 1.49(1.12, 1.96) 0.006
> 45 years old 174/997(17.5) 1 156/997(15.6) 1 100/997(10.0) 1
Dwelling state
Living alone 331/983(33.6) 1.56(1.32, 1.84) <0.001 237/984(24.1) 1.43(1.20, 1.69) <0.001 156/984(15.9) 1.87(1.50, 2.32) <0.001
Living together 1081/4692(23.0) 1 862/4692(18.4) 1 408/4692(8.7) 1
Having organic diseases
Yes 234/634(36.9) 2.20(1.82, 2.66) <0.001 196/634(30.9) 2.41(1.97, 2.95) <0.001 137/634(21.6) 2.33(1.83, 2.95) <0.001
No 892/3579(24.9) 1 611/3579(17.1) 1 394/3579(11.0) 1
Marital status
Unmarried 538/1767(30.4) 1.26(1.08, 1.47) 0.003 385/1767(21.8) 196/1767(11.1)
Married 874/3909(22.4) 1 714/3909(18.3) 368/3909(9.4)
Education level
Senior highschool or lower 245/823(29.8) 195/823(23.7) 126/823(15.3) 1.60(1.25, 2.06) <0.001
College or higher 1167/4853(24.0) 904/4853(18.6) 438/4853(9.0) 1
Occupation
Nonhealthcare workers 736/3460(21.3) 1.88(1.61, 2.20) <0.001 608/3460(17.6) 1.77(1.49, 2.10) <0.001 287/3460(8.30 1.25(1.00, 1.55) 0.047
Healthcare workers 676/2216(30.5) 1 491/2216(22.2) 1 277/2216(12.5) 1
Personal infection
Confirmed 42/167(25.10 1.19(0.82, 1.73) 0.357 41/161(24.60 1.65(1.13, 2.41) 0.009 45/167(26.9) 1.39(0.87, 2.22) 0.165
Suspected 40/101(39.6) 2.50(1.63, 3.83) <0.001 34/101(33.7) 2.77(1.79, 4.30) <0.001 49/101(48.5) 3.11(1.70, 5.69) <0.001
Quarantine 92/290(31.7) 2.02(1.50, 2.71) <0.001 100/290(34.5) 2.81(2.08, 3.79) <0.001 32/290(11.0) 1.94(1.28, 2.94) 0.002
Close contactor 353/1655(21.3) 1.50(1.19, 1.89) 0.001 306/1655(18.5) 1.36(1.05, 1.76) 0.021 79/1655(4.8) 1.41(1.02, 1.96) 0.038
No 885/3463(25.6) 1 618/3463(17.8) 1 359/3463(10.4) 1