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. 2020 Oct 30;39(23):e104369. doi: 10.15252/embj.2019104369

Figure 9. Phosphorylation acts as a switch for inter‐organelle contact formation.

Figure 9

Schematic representation of the two types of FFATs: (left) conventional FFATs (illustrated here with STARD11/CERT) which allow the formation of a stable complex between VAPs/MOSPD2 and thus the formation of MCSs; (right) a novel type of FFATs that we named Phospho‐FFATs (illustrated here with STARD3), which strictly depend on phosphorylation to be active. Thus, phosphorylation acts as a switch mechanism to turn on the interaction between VAPs/MOSPD2 and their partners possessing a Phospho‐FFAT, and thus membrane contact site formation.