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. 2020 Nov 26;12(11):1396–1409. doi: 10.4252/wjsc.v12.i11.1396

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Oxygen-glucose deprived-human neural stem cells-condition medium further promotes glioma cell proliferation and invasion. A: The proliferation of U87 and U251 MG cells was significantly increased in the condition medium (CM) groups, especially in the oxygen-glucose deprived-human neural stem cells (hNSC)-CM group, as measured by CCK8 assay; B-E: hNSC-CM promoted the invasion ability of glioma cells (U87 MG shown in B and C, U251 MG shown in D and E) compared to unconditioned hNSC medium, especially in the oxygen-glucose deprived-hNSC-CM group. Control: Unconditioned hNSC medium group. ^aP < 0.05 vs Control, ^bP < 0.01 vs Control, ^cP < 0.05 vs hNSC-CM. OGD: Oxygen-glucose deprived; hNSCs: Human neural stem cells; CM: Condition medium.