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. 2020 Nov 26;12(11):1295–1306. doi: 10.4252/wjsc.v12.i11.1295

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Metabolic targeted therapy of breast cancer stem cells. Breast cancer stem cells (BCSCs) have been demonstrated to contribute to tumor heterogeneity and relapse (metastasis and tumor recurrence). The metabolic features of BCSCs significantly differ from those of non-BCSC differentiated tumor cells. Conventional chemotherapy or radiotherapy can effectively kill breast cancer cells, thereby dramatically reducing tumor size. The remaining BCSCs can survive and enhance tumor relapse due to their ability to establish higher invasiveness and resistance to chemotherapy and radiotherapy. A combination treatment with metabolic targeted therapy of BCSCs and conventional therapy could be a more effective strategy to treat breast cancer. BCSCs: Breast cancer stem cells; BC: Breast cancer.