Figure 1.

Tumor microenvironment in breast cancer. The figure describes the microenvironment present in cancer development. The tumor grows in an allowable microenvironment delimited by an extracellular matrix and inside there is a series of biomolecules such as cytokines, chemokines, miRNAs, growth factors. Furthermore, different cell types, such as breast cancer stem cells, platelets, tumor-associated macrophages, mesenchymal stem cells, and cancer-associated fibroblasts, contribute to the optimal conditions for cancer development. Biomolecules and cells, all orchestrate to promote tumor growth, angiogenesis, epithelial-mesenchymal transition, and metastasis. Created by Biorender.com. BCSC: Breast cancer stem cells; MSC: Mesenchymal stem cell; ECM: Extracellular matrix; TAM: Tumor-associated macrophage; CAF: Cancer-associated fibroblast. Created with Biorender.com