Table 2.

Tumourcharacteristics—treatment

	Study group						P value
	Single primary uveal mel. (n=3863)		Second primary uveal mel. (n=437)		Primary uveal mel. followed by another primary malignancy (n=646)
	N	Col. N %	N	Col. N %	N	Col. N %
Site
C69.3-Choroid	3235	83.7	361	82.6	516	79.9	0.016
C69.4-Ciliary body	628	16.3	76	17.4	130	20.1
Histology
8720/3: Malignant, NOS	2511	65.0	309	70.7	397	61.5	0.288
8726/3: Malignant in magnocellular nevus	1	0.0	0	0.0	0	0.0
8730/3: Amelanotic	30	0.8	5	1.1	4	0.6
8742/3: Lentigo maligna	1	0.0	0	0.0	0	0.0
8743/3: Superficial spreading	0	0.0	0	0.0	1	0.2
8770/3: Mixed epithelioid and spindle cell	454	11.8	53	12.1	85	13.2
8771/3: Epithelioid cell	190	4.9	14	3.2	16	2.5
8772/3: Spindle cell, NOS	253	6.5	25	5.7	55	8.5
8773/3: Spindle cell, type A	35	0.9	0	0.0	8	1.2
8774/3: Spindle cell, type B	388	10.0	31	7.1	80	12.4
Stage
Localised	3176	91.8	348	90.2	551	94.8	0.023
Regional	222	6.4	27	7.0	28	4.8
Distant	63	1.8	11	2.8	2	0.3
Size
5 mm or less	109	7.2	11	6.5	34	11.5	0.097
6–10 mm	432	28.6	49	29.0	89	30.1
11–15 mm	547	36.3	56	33.1	95	32.1
More than 15 mm	420	27.9	53	31.4	78	26.4
Grade
Well differentiated; Grade I	37	35.9	5	38.5	3	37.5	0.653
Moderately differentiated; Grade II	47	45.6	5	38.5	5	62.5
Poorly differentiated; Grade III	18	17.5	2	15.4	0	0.0
Undifferentiated; anaplastic; grade IV	1	1.0	1	7.7	0	0.0
Confirmation
Positive histology	2420	63.2	248	57.4	456	71.4	0.003
Positive exfoliative cytology, no positive histology	122	3.2	22	5.1	10	1.6
Positive microscopic confirm, method not specified	9	0.2	3	0.7	4	0.6
Positive laboratory test/marker study	3	0.1	2	0.5	3	0.5
Direct visualisation without microscopic confirmation	443	11.6	70	16.2	64	10.0
Radiography without microscopic confirm	625	16.3	73	16.9	70	11.0
Clinical diagnosis only	205	5.4	14	3.2	32	5.0