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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Endocrinol Metab Clin North Am. 2020 Dec;49(4):741–757. doi: 10.1016/j.ecl.2020.08.002

Table 4.

Commonly Used Estrogen and Progesterone Formulations for Hypogonadism in the United States

Estrogen Formulation Brand Name Initiation Dose1 Adult Dose
Transdermal
 • Patch Vivelle 6.25–12.5 mcg twice weekly 25–100 mcg twice weekly
Oral
 • Micronized 17β-estradiol Estrace 0.25 mg daily 1–4 mg daily
Progesterone Formulation Notes for Clinical Care Adult Dose2
Oral
 • Medroxyprogesterone acetate
 • Micronized progesterone		 Provera
Prometrium		 Progestin added after first episode of vaginal bleeding or after 2 years of estrogen treatment 10 mg daily for 10 days each month
100–200 mg daily for 10–21 days each month or continuously
Estrogen and Progesterone Formulation Notes for Clinical Care Adult Dose
Oral Contraceptive Pill (OCP) Do not use OCP to initiate puberty. Multiple types with various doses of estrogen and progestin.
1

Increase estradiol dose every 6 months over 2–3 year period with goal of adult dosing range.

2

Given with estradiol.