Table 3.
Cox regression model to predict RFS and OS of c‐N0 subcentimeter lung adenocarcinoma
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P‐value | HR (95% CI) | P‐value |
| RFS | ||||
| Sex (female) | 0.48 (0.25–0.94) | 0.031 | 0.53 (0.27–1.06) | 0.072 |
| Age (>65) | 1.04 (0.47–2.28) | 0.930 | ||
| Smoking (yes) | 1.37 (0.64–2.93) | 0.413 | ||
| Tumor location (lower) | 0.61 (0.26–1.46) | 0.266 | ||
| Total size (cm) | 1.46 (0.32–6.58) | 0.625 | ||
| Predominant component | ||||
| Lepidic | Reference | 0.053 | a | |
| Acinar | 2.06 (0.91–4.66) | 0.083 | a | |
| Papillary | 1.80 (0.67–4.84) | 0.242 | a | |
| Solid | 0.94 (0.12–7.45) | 0.956 | a | |
| Micropapillary | 9.52 (2.05–44.17) | 0.004 | a | |
| Lepidic (present) | 0.65 (0.34–1.28) | 0.214 | ||
| Acinar (present) | 1.36 (0.64–2.91) | 0.425 | ||
| Papillary (present) | 0.60 (0.31–1.17) | 0.131 | ||
| Solid (present) | 1.82 (0.71–4.70) | 0.214 | ||
| Micropapillary (present) | 3.93 (1.98–7.82) | <0.001 | 3.90 (1.93–7.87) | <0.001 |
| VPI (present) | 0.69 (0.23–2.03) | 0.495 | ||
| Nodal involvement (present) | 6.83 (2.09–22.33) | 0.001 | 5.42 (1.58–18.65) | 0.007 |
| Surgery | ||||
| Lobectomy | reference | 0.051 | 0.009 | |
| Segmentectomy | 0.61 (0.14–2.57) | 0.496 | 0.45 (0.10–1.94) | 0.283 |
| Wedge resection | 2.50 (1.11–5.60) | 0.026 | 3.13 (1.38–7.13) | 0.007 |
| OS | ||||
| Sex (female) | 0.58 (0.27–1.28) | 0.179 | ||
| Age (> 65) | 1.77 (0.76–4.12) | 0.184 | ||
| Smoking (yes) | 1.66 (0.69–4.01) | 0.257 | ||
| Tumor location (lower) | 0.78 (0.30–2.06) | 0.616 | ||
| Total size (cm) | 1.66 (0.26–10.39) | 0.590 | ||
| Predominant component | ||||
| Lepidic (reference) | 0.001 | a | ||
| Acinar | 1.95 (0.71–5.38) | 0.195 | a | |
| Papillary | 1.97 (0.60–6.45) | 0.264 | a | |
| Solid | 1.43 (0.17–11.93) | 0.738 | a | |
| Micropapillary | 19.76 (4.85–80.42) | <0.001 | a | |
| Lepidic (present) | 0.46 (0.21–1.00) | 0.050 | 0.91 (0.35–2.39) | 0.849 |
| Acinar (present) | 1.24 (0.52–2.98) | 0.626 | ||
| Papillary (present) | 0.58 (0.26–1.26) | 0.169 | ||
| Solid (present) | 2.58 (0.97–6.88) | 0.059 | 1.49 (0.48–4.61) | 0.489 |
| Micropapillary (present) | 5.73 (2.39–13.76) | <0.001 | 6.09 (2.33–15.94) | <0.001 |
| VPI (present) | 0.18 (0.02–1.35) | 0.095 | 0.19 (0.02–1.41) | 0.104 |
| Nodal involvement (present) | 4.82 (1.11–20.93) | 0.036 | 4.50 (1.01–20.00) | 0.048 |
| Surgery | ||||
| Lobectomy (reference) | 0.002 | 0.002 | ||
| Segmentectomy | 0.62 (0.08–4.80) | 0.651 | 0.47 (0.06–3.69) | 0.470 |
| Wedge resection | 4.61 (1.92–11.08) | 0.001 | 4.61 (1.86–11.46) | 0.001 |
a
Predominant component was not included in multivariate analysis because of the association with presence of each components in adenocarcinoma. CI, confidence interval; HR, hazard ratio.