Table 3.
Putative Targets of CA Identified by TargetNet and SwissTarget
| RANK | Uniprot ID | Name | Target Gene |
|---|---|---|---|
| 1 | P30542 | Adenosine A1 receptor | ADORA1 |
| 2 | P29274 | Adenosine A2a receptor | ADORA2A |
| 3 | P13866 | Sodium/glucose cotransporter 1 | SLC5A1 |
| 4 | P29275 | Adenosine A2b receptor | ADORA2B |
| 5 | O43570 | Carbonic anhydrase XII | CA12 |
| 6 | Q9ULX7 | Carbonic anhydrase XIV | CA14 |
| 7 | Q16790 | Carbonic anhydrase IX | CA9 |
| 8 | P08253 | Matrix metalloproteinase 2 | MMP2 |
| 9 | P31639 | Sodium/glucose co-transporter 2 | SLC5A2 |
| 10 | P00533 | Epidermal growth factor receptor erbB1 | EGFR |
| 11 | P11387 | DNA topoisomerase I | TOP1 |
| 12 | P12268 | Inosine-5ʹ-monophosphate dehydrogenase 2 | IMPDH2 |
| 13 | P34913 | Epoxide hydratase | EPHX2 |
| 14 | P35354 | Cyclooxygenase-2 | PTGS2 |
| 15 | P25101 | Endothelin receptor ET-A | EDNRA |
| 16 | P07900 | Heat shock protein HSP 90-alpha | HSP90AA1 |
| 17 | Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
| 18 | P26358 | DNA (cytosine-5)-methyltransferase 1 | DNMT1 |
| 19 | P43166 | Carbonic anhydrase VII | CA7 |
| 20 | Q8N1Q1 | Carbonic anhydrase XIII | CA13 |
| 21 | P23219 | Cyclooxygenase-1 | PTGS1 |
| 22 | P08473 | Neprilysin | MME |
| 23 | P11362 | Fibroblast growth factor receptor 1 | FGFR1 |
| 24 | Q06187 | Tyrosine-protein kinase BTK | BTK |
| 25 | Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
| 26 | P22748 | Carbonic anhydrase IV | CA4 |