Table 2.
Gene expression in SOD1-G93A mice.
| Gene name | log2FC | padj |
|---|---|---|
| Genes uniquely altered in IL-10 cohort | ||
| Fcrls | 1.84 | 7.62E−05 |
| mSOD1 | − 0.43 | 0.002 |
| Hprt1 | − 0.39 | 0.003 |
| GAPDH | − 0.31 | 0.005 |
| Pink1 | − 0.43 | 0.007 |
| Mapk8 | − 0.38 | 0.007 |
| hSOD1 | − 0.40 | 0.007 |
| Itgb2/MAC-1 | 1.05 | 0.018 |
| Creb1 | − 0.42 | 0.032 |
| eif2alpha | − 0.38 | 0.033 |
| Ccl11 | − 1.26 | 0.037 |
| CARD9 | 0.74 | 0.039 |
| SNCA | − 0.42 | 0.041 |
| Cfl1 | − 0.29 | 0.042 |
| Genes uniquely altered in IL-10 + M3 cohort | ||
| Cd68 | 1.04 | 1.98E−04 |
| B2M | 1.16 | 6.69E−04 |
| Cxcl9 | 2.14 | 9.00E−04 |
| Cfb | 1.46 | 5.78E−03 |
| Ctsd | 0.34 | 1.07E−02 |
| IL-6 | 2.92 | 0.011 |
| MARCO | 2.63 | 0.013 |
| Limk1 | − 0.40 | 0.019 |
| Mapt ex10 | 1.86 | 0.021 |
List of significant DEGs in the AAV-IL-10 cohort and the AAV-IL-10 + AAV-M3 cohort that are exclusively altered in individual cohort. Data is derived from RNA analysis using a NanoString custom code set. log2 FC = log2 of fold change; padj = Benjamini–Hochberg adjusted p value.