Fig. 3. Impact of the proposed model on clinical practice for patients with suspicion of AIS in the emergency department.

In the cohort of patients with suspected AIS (Internal cohort 5), who were prescribed to perform head CTA examination, 86.8% patients diagnosed as aneurysm-negative cases by our model, among which 99.0% were true-negative, demonstrating high confidence in identifying negative cases by our model. As a result, only 13.2% of patients were categorized as high-risk, to whom the radiologists can pay more-intense attention and reduce their workload in detecting aneurysm in AIS patients. AIS acute ischemic stroke, IA intracranial aneurysm.