Table 1.

Promiscuous Ligand Recognition by FPRs.

Source Diseases	Agonists	FPR1	FPR2	FPR3
		(Fpr1)	(Fpr2)	(Fpr3)
Bacteria Infection	fMLF (E. Coli)	++++	++
	Listeria peptides	++++	+++
Stomach cancer	Hp(2-20)	-	+++	++
Host Inflammation	Serum amyloid A	-	++++
Alzheimer’s	Aβ42, Humanin	+	++++
Prion disease	Prp106-126	-	+++
Angiogenesis	Annexin 1(ANXA1)	++	+++	++
Tissue damage	Mitochondria pep	+++	+++
	F2 L (Heme)	-	++	++++
Coagulation	uPAR frag	-	+++
Host defense	LL37 (CRAMP)	-	+++
	Cathepsin G		+++
Cancer	ANXA1	++	+++

+ Denotes the relative potency of the ligands to activate a given FPR References: 1, 2, 16).