Table 3.
Histopathological findings in the liver of a series of 14 patients deceased due to COVID-19 infection
| Patient No. | Centrilobular necrosis | Steatosis | Lobular infl. | Portal inflammation | Fibrosis, METAVIR score | Bile duct proliferation | Cholestasis | Iron overload | Findings identified by PAS staining |
|---|---|---|---|---|---|---|---|---|---|
| 1 | + | − | + | + | F0 | − | + | − | − |
| 2 | ++/+++ | + | − | − | F0 | + | − | − | − |
| 3 | +/++ | + | − | + | F0 | − | + | + | CM |
| 4 | + | − | − | +/++a | F1 | + | − | ++ | − |
| 5 | − | + | + | ++ | F3 | + | − | − | CM |
| 6 | + | ++ | + | + | F1 | − | + | + | − |
| 7 | +++ | − | ++b | + | F0 | − | − | + | − |
| 8 | ++ | + | ++b | ++b | F0 | + | − | − | − |
| 9 | ++ | + | − | ++ | F2 | + | + | − | − |
| 10 | ++ | − | + | + | F0 | − | + | + | − |
| 11 | − | + | − | + | F0 | − | − | − | − |
| 12 | + | + | + | + | F0 | − | − | − | − |
| 13* | Autolysis | Autolysis | Autolysis | Autolysis | F0 | Autolysis | Autolysis | − | Autolysis |
| 14 | ++ | + | + | ++ | F0 | − | − | − | − |
CM, ceroid macrophages. −, absent; +, mild; ++, moderate; +++, severe.
*
We were unable to reliably evaluate the liver of patient 13 due to the presence of extensive autolysis.
a
Prominent eosinophilic infiltrate.
b
Prominent neurophilic infiltrate.