Table 2. Key Residues of the 12–α-Cbtx Interaction (PDB 6ZFM) in Comparison to the nAChR−α-Bgtx Complex.

α-Cbtx	12-A	12-B	α-Bgtx	nAChR (PDB 6UWZ)
D27	Y7 (H bond)	Y1 (H bond)	D30	αY190 (H bond)
F29		W6 (π–π)	F32	γW55/δW57, αW149 (hydrophobic)
R33	W3, Y7 (cation−π)	Y1, W6 (cation−π)	R36	Y190α, Y198α (cation−π); γW55/δW57, αW149 (hydrophobic)
R36	D4 (salt bridge)	Y1 (hydrophobic)	V39
F65	W6 (hydrophobic)		H68	backbone (H-bond)