Supplementary Table 10.

Molecular functions identified by gene set enrichment analysis in A–F1 versus N–F1 contrast

Molecular functions	NES	FDR
Microtubule motor activity	−2.82	0.00
Motor activity	−2.47	0.00
Ligase activity	−2.39	0.00
Helicase activity	−2.36	0.00
Nuclear localization sequence binding	−2.35	0.00
RAN GTPase binding	−2.33	0.00
Ubiquitin-like protein-specific protease activity	−2.32	0.00
Signal sequence binding	−2.30	0.00
Tubulin binding	−2.30	0.00
Protein serine threonine kinase activity	−2.29	0.00
Thiol-dependent ubiquitin-specific protease activity	−2.28	0.00
Ubiquitin-like protein ligase activity	−2.26	0.00
ATPase activity	−2.25	0.00
Microtubule binding	−2.24	0.00
Nucleocytoplasmic transporter activity	−2.23	0.00
Translation initiation factor activity	−2.23	0.00
Ubiquitin-like protein binding	−2.18	0.00
Translation factor activity RNA binding	−2.16	0.00
DNA-dependent ATPase activity	−2.14	0.00
Peptide N acetyltransferase activity	−2.10	0.00
Purine NTP-dependent helicase activity	−2.10	0.00
Ubiquitin-like protein transferase activity	−2.09	0.00
Protein transporter activity	−2.08	0.00
mRNA binding	−2.05	0.00
RNA helicase activity	−2.04	0.00
DNA-directed DNA polymerase activity	−2.03	0.00
Lysine acetylated histone binding	−2.03	0.00
Histone lysine N methyltransferase activity	−2.03	0.00
GTPase binding	−2.03	0.00
Phosphatidylinositol phosphate phosphatase activity	−2.01	0.00
ATP-dependent microtubule motor activity	−2.01	0.00

The 31 molecular functions showed in this table were selected on the basis of NES ≥2.0 and FDR <0.05. The molecular signature database (v6.2) searched was molecular functions using GSEA approach (http://www.broadinstitute.org/gsea). The ten molecular functions in bold text were included in the leading-edge analysis. NES: normalized enrichment score; FDR: false discovery rate