Supplementary Table 8.
Biological processes identified by gene set enrichment analysis in A–F1 versus N–F1 contrast
| Biological processes | NES | FDR |
|---|---|---|
| Cilium morphogenesis | −2.77 | 0.00 |
| Microtubule-based movement | −2.76 | 0.00 |
| Cilium organization | −2.74 | 0.00 |
| Microtubule-based process | −2.70 | 0.00 |
| Male gamete generation | −2.60 | 0.00 |
| Chromosome segregation | −2.60 | 0.00 |
| Cellular component assembly involved in morphogenesis | −2.59 | 0.00 |
| Microtubule organizing center organization | −2.59 | 0.00 |
| Spermatid differentiation | −2.55 | 0.00 |
| Microtubule cytoskeleton organization | −2.54 | 0.00 |
| Organelle fission | −2.53 | 0.00 |
| Meiotic cell cycle | −2.53 | 0.00 |
| Meiotic cell cycle process | −2.52 | 0.00 |
| Meiotic chromosome segregation | −2.51 | 0.00 |
| Cell projection assembly | −2.51 | 0.00 |
| Nuclear chromosome segregation | −2.50 | 0.00 |
| Nuclear export | −2.47 | 0.00 |
| Meiosis I | −2.46 | 0.00 |
| Male meiosis | −2.45 | 0.00 |
| Centrosome cycle | −2.45 | 0.00 |
| Golgi vesicle transport | −2.43 | 0.00 |
| Protein modification by small protein removal | −2.42 | 0.00 |
| RNA localization | −2.40 | 0.00 |
| Regulation of cellular response to heat | −2.40 | 0.00 |
| Organelle assembly | −2.40 | 0.00 |
| Golgi to vacuole transport | −2.39 | 0.00 |
| Golgi organization | −2.39 | 0.00 |
| Reciprocal DNA recombination | −2.35 | 0.00 |
| Cytoskeleton-dependent intracellular transport | −2.34 | 0.00 |
| Cell cycle G2 M phase transition | −2.33 | 0.00 |
| Sperm motility | −2.33 | 0.00 |
| Axonemal dynein complex assembly | −2.33 | 0.00 |
| Mitotic nuclear division | −2.32 | 0.00 |
| Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | −2.31 | 0.00 |
| Centrosome duplication | −2.29 | 0.00 |
| Establishment of localization by movement along microtubule | −2.29 | 0.00 |
| Sister chromatid cohesion | −2.29 | 0.00 |
| Ribonucleoprotein complex localization | −2.28 | 0.00 |
| Sperm–egg recognition | −2.26 | 0.00 |
| tRNA transport | −2.26 | 0.00 |
| Post Golgi vesicle-mediated transport | −2.26 | 0.00 |
| Intra Golgi vesicle-mediated transport | −2.26 | 0.00 |
| Sister chromatid segregation | −2.25 | 0.00 |
| Multiorganism localization | −2.25 | 0.00 |
| Cilium movement | −2.25 | 0.00 |
| DNA synthesis involved in DNA repair | −2.25 | 0.00 |
| Mitotic spindle organization | −2.25 | 0.00 |
| Germ cell development | −2.24 | 0.00 |
| Nucleobase-containing compound transport | −2.24 | 0.00 |
| Nucleus organization | −2.24 | 0.00 |
| Nuclear envelope organization | −2.24 | 0.00 |
| Chromosome separation | −2.23 | 0.00 |
| Membrane disassembly | −2.23 | 0.00 |
| Protein transport along microtubule | −2.22 | 0.00 |
| DNA repair | −2.21 | 0.00 |
| Homologous chromosome segregation | −2.21 | 0.00 |
| Retrograde transport vesicle recycling within Golgi | −2.21 | 0.00 |
| Protein localization to Golgi apparatus | −2.20 | 0.00 |
| Fertilization | −2.20 | 0.00 |
| Synapsis | −2.20 | 0.00 |
| Chromosome organization involved in meiotic cell cycle | −2.19 | 0.00 |
| Golgi to endosome transport | −2.19 | 0.00 |
| Cytoplasmic microtubule organization | −2.19 | 0.00 |
| Spindle assembly | −2.19 | 0.00 |
| Peptidyl lysine modification | −2.18 | 0.00 |
| Cellular process involved in reproduction in multicellular organism | −2.18 | 0.00 |
| Protein polyubiquitination | −2.18 | 0.00 |
| Mitotic spindle assembly | −2.16 | 0.00 |
| Protein localization to vacuole | −2.16 | 0.00 |
| Microtubule bundle formation | −2.15 | 0.00 |
| Epithelial cilium movement | −2.14 | 0.00 |
| Cell–cell recognition | −2.14 | 0.00 |
| ER to Golgi vesicle-mediated transport | −2.14 | 0.00 |
| Axoneme assembly | −2.13 | 0.00 |
| Protein complex localization | −2.13 | 0.00 |
| DNA biosynthetic process | −2.13 | 0.00 |
| Cell division | −2.12 | 0.00 |
| Gene silencing by RNA | −2.11 | 0.00 |
| Regulation of chromosome segregation | −2.11 | 0.00 |
| Binding of sperm to zona pellucida | −2.09 | 0.00 |
| Protein sumoylation | −2.09 | 0.00 |
| Androgen receptor signaling pathway | −2.09 | 0.00 |
| Cell cycle phase transition | −2.08 | 0.00 |
| Spindle checkpoint | −2.08 | 0.00 |
| Protein localization to centrosome | −2.07 | 0.00 |
| Negative regulation of mRNA metabolic process | −2.07 | 0.00 |
| Intracellular steroid hormone receptor signaling pathway | −2.07 | 0.00 |
| Retrograde vesicle-mediated transport Golgi to ER | −2.06 | 0.00 |
| Regulation of organelle assembly | −2.06 | 0.00 |
| Single fertilization | −2.06 | 0.00 |
| Chromatin modification | −2.05 | 0.00 |
| Establishment of protein localization to vacuole | −2.05 | 0.00 |
| Endomembrane system organization | −2.05 | 0.00 |
| Postreplication repair | −2.04 | 0.00 |
| Male meiosis I | −2.04 | 0.00 |
| Nucleotide excision repair | −2.04 | 0.00 |
| Double-strand break repair | −2.03 | 0.00 |
| NLS-bearing protein import into nucleus | −2.03 | 0.00 |
| Regulation of proteasomal ubiquitin-dependent protein catabolic process | −2.02 | 0.00 |
| Organelle transport along microtubule | −2.02 | 0.00 |
| mRNA processing | −2.02 | 0.00 |
| DNA recombination | −2.02 | 0.00 |
| Vesicle coating | −2.02 | 0.00 |
| Regulation of microtubule-based process | −2.02 | 0.00 |
| RNA secondary structure unwinding | −2.02 | 0.00 |
| Regulation of proteasomal protein catabolic process | −2.01 | 0.00 |
| Protein export from nucleus | −2.01 | 0.00 |
| Negative regulation of protein complex disassembly | −2.01 | 0.00 |
| Myelin assembly | −2.01 | 0.00 |
| Gene silencing | −2.00 | 0.00 |
The 110 biological processes showed in this table were selected on the basis of NES ≥2.0 and FDR <0.05. The molecular signature database (v6.2) searched was biological processes using GSEA approach (http://www.broadinstitute.org/gsea). The ten biological processes in bold text were included in the leading-edge analysis. NES: normalized enrichment score; FDR: false discovery rate; GSEA: gene set enrichment analysis