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. 2020 Nov 12;23(1):48. doi: 10.3892/mmr.2020.11686

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Bcl-2/Bcl-xL inhibitor ABT-263 acts in synergy with osimertinib in non-small cell lung cancer cells. (A) HCC827/OR cells were treated with a combination of osimertinib and ABT-263 or each individual agent and cell viability was determined using a MTT assay. (B) CI of osimertinib and ABT-263 was calculated using the Chou-Talalay method. (C and D) Colony formation assay was used to determine the effects of the concurrent treatment of HCC827/OR cells with both osimertinib and ABT-263. *P<0.05 vs. treatment alone or control group. CI, combination index.