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. 2020 Nov 5;23(1):31. doi: 10.3892/mmr.2020.11669

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — STAT3 expression is negatively regulated by miR-495. (A) Bioinformatics analysis of predicted binding sites between miR-495 and STAT3. (B) The relative expression levels of STAT3 were significantly increased in CRC tissues. (C) Pearson's correlation analysis showed an inverse correlation between miR-495 and STAT3 expression in CRC tissues. (D) Luciferase reporter assays indicated that transfection with the miR-495 mimic significantly reduced the luciferase activity of STAT3-WT in HCT116 and SW480 cells. Overexpression of miR-495 significantly reduced the expression of STAT3 at the (E) mRNA and (F) protein levels in HCT116 and SW480 cells. ***P<0.001. CRC, colorectal cancer; miR, microRNA; si-, small interfering RNA; NC, negative control; WT, wild-type; MUT, mutant.