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. 2020 Nov 5;23(1):31. doi: 10.3892/mmr.2020.11669

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — SNHG20 regulates miR-495/STAT3 signaling in CRC. (A-C) SNHG20 knockdown decreased the mRNA and protein expression levels of STAT3, which was reversed by the addition of the miR-495 inhibitor in HCT116 and SW480 cells. (D) Pearson's correlation analysis indicated that SNHG20 expression was positively correlated with STAT3 expression in CRC tissues. (E) Reverse transcription-quantitative PCR and (F) western blotting indicated that the mRNA and protein levels of STAT3 were significantly increased following transfection of the cells with pcDNA3.1(+) STAT3. SNHG20 knockdown decreased the (G) mRNA and (H) protein expression levels of STAT3, which could be reversed by STAT3 overexpression. ***P<0.001. SNHG20, small nucleolar RNA host gene 20; CRC, colorectal cancer; miR, microRNA; si-, small interfering RNA; NC, negative control.