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Influence of ABCC1 expression on the activity of COTI-2. Anticancer activity of COTI-2 was tested in GLC-4 and GLC-4/adr lung cancer cells by the MTT assay after 72 h drug incubation. Vincristine, a known ABCC1 substrate, was used as a reference drug. Values given are means ± SD of three experiments performed in triplicates. The insert shows a Western blot of membrane-enriched protein fractions confirming the overexpression of ABCC1 in GLC-4/adr compared to parental GLC-4 cells.
