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. 2020 Nov 16;63(22):13719–13732. doi: 10.1021/acs.jmedchem.0c01277

Figure 6.

Figure 6

Impact of ABC transporter modulators (1 μM CSA and 10 μM verapamil) on the anticancer activities of vincristine, COTI-2, COTI-NH2, and Triapine in the SW480/Coti cells in comparison to the parental cells. Vincristine was used as a positive control of an ABCC1 substrate. Viability was measured by the MTT assay after 72 h of combined drug treatment. Mean ± SD was derived from triplicates of one representative experiment out of three. Values are given normalized to their respective controls. Thus, modulator controls were set to 1.