. 2020 Nov 16;63(22):13719–13732. doi: 10.1021/acs.jmedchem.0c01277

Table 1. Anticancer Activity (IC₅₀ Values after 72 h) of the Indicated Thiosemicarbazones and Metal Complexes in SW480 and Thiosemicarbazone-Resistant SW480/Coti and SW480/Tria Colon Cancer Cells.

compound	SW480 (IC₅₀, μM)^a	SW480/Coti (IC₅₀, μM)^a	relative resistance^b	SW480/Tria (IC₅₀, μM)^a	relative resistance^b
COTI-2	0.56 ± 0.16	9.51 ± 3.11	18.9*	0.41 ± 0.16^.	0.8^n.s
Triapine	0.82 ± 0.18	0.81 ± 0.08	1.0^n.s.	>50^c	>61
COTI-NH₂	7.85 ± 0.92	4.39 ± 0.56	0.6^***	>20	>2.5
Fe-COTI-2	9.32 ± 3.29	7.13 ± 2.91	0.7^n.s.	3.62 ± 0.80	0.3^**
Cu-COTI-2	0.04 ± 0.01	0.48 ± 0.05	12.0^**	0.04 ± 0.01	1.1^n.s.

IC₅₀ values were calculated from concentration–response curves. Values are given as mean ± SD of three independent experiments performed in triplicates.

Differences in sensitivity calculated by dividing the IC₅₀ values of the resistant subline by those of the parental line. ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05; n.s. (not significantly different), calculated by one-sample t-test.

Taken from ref.⁹

Table 1. Anticancer Activity (IC50 Values after 72 h) of the Indicated Thiosemicarbazones and Metal Complexes in SW480 and Thiosemicarbazone-Resistant SW480/Coti and SW480/Tria Colon Cancer Cells.

Table 1. Anticancer Activity (IC₅₀ Values after 72 h) of the Indicated Thiosemicarbazones and Metal Complexes in SW480 and Thiosemicarbazone-Resistant SW480/Coti and SW480/Tria Colon Cancer Cells.