Table 1.

Independent relationships of ORR with explanatory variables

Explanatory variable	Metaregression coefficient [95% CI]	P	Datasets
Age (years)	0.87 [−0.641, 2.390]	= 0.246	29
Females (%)	−0.241 [−1.078, 0.597]	= 0.561	32
Follow-up duration (months)	−0.037 [−0.735, 0.661]	= 0.914	29
% patients with TNM M0	0.018 [−0.276, 0.314]	= 0.892	14
% patients with TNM M1a	1.201 [0.464, 1.938]	= 0.004	14
% patients with TNM M1b	1.259 [0.414, 2.104]	= 0.007	14
% patients with TNM M1c	−0.857 [−1.251, −0.463]	<0.00001	19
% patients with brain metastasis	0.043 [−0.219, 0.306]	= 0.736	23
% patients with 0 ECOG PS	0.596 [0.133, 1.060]	= 0.014	23
% patients with 1 ECOG PS	−0.180 [−0.969, 0.610]	= 0.644	28
% patients with BRAF mutations	−0.110 [−0.565, 0.345]	= 0.622	26
% patients with high LDH levels	−0.355 [−0.777, 0.066]	= 0.094	26
% patients with PD-L1 positivity	0.119 [−0.137, 0.375]	= 0.326	12
% patients with prior therapy	−0.240 [−0.392, −0.088]	= 0.003	32