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Relationship between serum concentrations of biomarkers at baseline and the efficacy of pirfenidone on changes in vital capacity from baseline. All patients were dichotomized by the median concentration of a SP-D, b SP-A and c KL-6 at baseline to the high and low biomarker subgroups. Blue lines, pirfenidone; black lines, placebo. Mean ± SE. Mean changes were calculated with the mixed model for repeated measurement (MMRM). *p < 0.05, **p < 0.01
