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. 2020 Nov 30;8:207. doi: 10.1186/s40478-020-01086-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — OMGP-specific T cells pave the way for anti-MOG mediated demyelination in gray and white matter of the spinal cord. Lewis rats were injected with OMGP-specific T cells, 2 days later either a control Ig (IvIg) (a) or the MOG-Ab 8-18C5-hIgG1 (b) was given and after 3 more days, the animals were sacrificed. Cross sections of the spinal cord were stained with H&E (left), LFB (middle), or Bielschowsky’s Silver Staining (right). b T cells injected together with MOG antibody (8-18C5-hIgG1), demyelination and neuronal destruction shown by Bielschowsky’s staining. Large demyelinating areas are seen in the white matter (upper part of b) and in white plus gray matter (lower part of b) along with axonal injury. Scale bar represents 1 mm. c Spinal cord (SC) demyelination (DM) was quantified from the LFB staining. The area of DM is shown in mm² per SC section. (p < 0.001 ***; t-test)