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. 2020 Sep 15;4(12):1851–1863. doi: 10.1002/hep4.1597

FIG. 3.

FIG. 3

miR‐125b‐5p overexpression does not cause abnormal liver regeneration at day 14 and 48 hours after 2/3 PH. (A) Schematic representation of the experimental design. (B) qRT‐PCR analysis revealed overexpression of miR‐125b‐5p at day 14 after 2/3 PH in liver of mice injected with AAV8‐Ttr‐miR‐125b‐5p compared to mice injected with control AAV. (C) Liver to body weight ratio. (D,E) Representative photographs of (D) Ki67‐ and (E) PHH3‐immunostained liver sections in miR‐125b‐5p‐overexpressing livers and control mice at day 14 after 2/3 PH. (F) Schematic representation of the experimental design. (G) qRT‐PCR analysis revealed overexpression of miR‐125b‐5p at 2 days after 2/3 PH in liver of mice injected with AAV8‐Ttr‐miR‐125b‐5p compared to mice injected with control AAV. (H) Liver to body weight ratio at 2 days after 2/3 PH. (I,J) Representative photographs of (I) Ki67‐ and (J) PHH3‐immunostained liver sections in miR‐125b‐5p‐overexpressing livers and control mice at day 2 after 2/3 PH. *P < 0.05, **P < 0.01; data are presented as mean ± SEM (n = 4 per group). Abbreviation: n.s., not significant.