Table 1.
Demographics and baseline characteristics of participants with BA SNL at age 2 years
| Variable | BASIC (N = 44) | PROBE (N = 196) | Total (N = 240) | ||||
|---|---|---|---|---|---|---|---|
| N | n (%) or Median (IQR) | N | n (%) or Median (IQR) | N | n (%) or Median (IQR) | ||
| Demographics | |||||||
| Female | 44 | 28 (63.6%) | 196 | 104 (53.1%) | 240 | 132 (55%) | |
| Race | White | 43 | 21 (48.8%) | 195 | 108 (55.4%) | 238 | 129 (54.2%) |
| Black | 43 | 7 (16.3%) | 195 | 29 (14.9%) | 238 | 36 (15.1%) | |
| Other | 43 | 15 (34.9%) | 195 | 58 (29.7%) | 238 | 73 (30.7%) | |
| Hispanic ethnicity | 42 | 5 (11.9%) | 196 | 48 (24.5%) | 238 | 53 (22.3%) | |
| Age at Kasai (days) | 44 | 61 (40, 76) | 196 | 57 (43, 74) | 240 | 59 (42, 74) | |
| Associated anomalies | |||||||
| Asplenia/polysplenia | 37 | 1 (2.7%) | 195 | 8 (4.1%) | 232 | 9 (3.9%) | |
| Cardiovascular anomaly | 37 | 5 (13.5%) | 195 | 30 (15.4%) | 232 | 35 (15.1%) | |
| Gastrointestinal anomaly | 37 | 8 (21.6%) | 195 | 18 (9.2%) | 232 | 26 (11.2%) | |
| Clinical features | |||||||
| History of GI bleed | 44 | 1 (2.3%) | 196 | 10 (5.1%) | 240 | 11 (4.6%) | |
| History of cholangitis | 44 | 23 (52.3%) | 196 | 81 (41.3%) | 240 | 104 (43.3%) | |
| History of ascites | 44 | 8 (18.2%) | 196 | 34 (17.3%) | 240 | 42 (17.5%) | |
| History of splenomegaly | 44 | 21 (47.7%) | 196 | 117 (59.7%) | 240 | 138 (57.5%) | |
| Weight growth failure | 35 | 4 (11.4%) | 178 | 6 (3.4%) | 213 | 10 (4.7%) | |
| Height growth failure | 35 | 0 (0%) | 179 | 13 (7.3%) | 214 | 13 (6.1%) | |
| Antibiotics | 27 | 11 (40.7%) | 194 | 58 (29.9%) | 221 | 69 (31.2%) | |
| Ursodeoxycholic acid | 27 | 17 (63%) | 189 | 123 (65.1%) | 216 | 140 (64.8%) | |
| Laboratory features | |||||||
| TB (mg/dL) | 41 | 0.5 (0.3, 1.3) | 186 | 0.5 (0.3, 0.9) | 227 | 0.5 (0.3, 0.9) | |
| GGT (U/L) | 35 | 127 (50, 239) | 152 | 134 (43, 332) | 187 | 130 (43, 327) | |
| Platelet count (×103/µL) | 38 | 189 (132, 246) | 179 | 206 (134, 280) | 217 | 205 (134, 271) | |
| APRI | 36 | 1.1 (0.7, 2.7) | 176 | 1.2 (0.6, 2.1) | 212 | 1.2 (0.7, 2.2) | |
| AST (U/L) | 40 | 80 (56, 138) | 189 | 88 (56, 159) | 229 | 84 (56, 154) | |
| ALT (U/L) | 40 | 65 (39, 117) | 189 | 85 (45, 163) | 229 | 83 (42, 155) | |
| Albumin (g/dL) | 39 | 4.1 (3.8, 4.4) | 187 | 4.1 (3.8, 4.4) | 226 | 4.1 (3.8, 4.4) | |
| INR | 30 | 1.0 (1.0, 1.2) | 161 | 1.0 (1.0, 1.1) | 191 | 1.0 (1.0, 1.1) | |