Table 8.

Metastasis-Related Genes Differentially Regulated Between Wild-Type and Kai1/Cd82^−/− MEFs by Twofold at P < 0.01

Affymetrix Id	Gene	Description	M KO signal	M WT signal	F KO signal	F WT signal	KO/WT Male	P-value	KO/WT Female	P-value
1419872_at	Csf1r	Colony-stimulating factor 1 receptor	524	2,160	1,353	919	0.243	2E–08	1.472	4E–06
1416298_at	Mmp9	Matrix metallopeptidase 9	147	604	110	144	0.243	4E–06	0.760	0.1135
1416401_at	Cd82	CD82 antigen	192	640	234	466	0.299	2E–08	0.502	1E–06
1451866_a_at	Hgf	Hepatocyte growth factor	44	136	37	56	0.324	3E–05	0.664	0.0535
1420798_s_at	Pcdha1	Protocadherin alpha 1	55	145	88	55	0.376	0.0001	1.587	0.016
1424341_s_at	Pcdha6	Protocadherin alpha 6	42	103	57	42	0.405	9E–05	1.343	0.0479
1433930_at	Hpse	Heparanase	56	115	45	53	0.484	0.0006	0.843	0.5041
1450040_at	Timp2	Tissue inhibitor of metalloproteinase 2	5,720	2,757	6,422	4,914	2.074	8E–07	1.307	0.0009
1435277_x_at	Nme1	Non-metastatic cells 1	9,273	4,221	9,701	6,782	2.197	0.0022	1.430	0.0506
1425092_at	Cdh10	Cadherin 10	1,178	510	881	1,085	2.310	2E–07	0.812	0.013
1449153_at	Mmp12	Matrix metallopeptidase 12	566	213	1,001	602	2.654	3E–06	1.663	8E–05
1420558_at	Selp	Selectin, platelet	142	48	179	118	2.987	7E–07	1.522	0.0162
1419675_at	Ngf	Nerve growth factor	4,689	1,450	4,026	4,006	3.234	6E–10	1.005	0.9273
1426731_at	Des	Desmin	776	239	513	394	3.247	2E–07	1.301	0.0391
1421997_s_at	Itga3	Integrin alpha 3	105	28	217	180	3.701	0.0021	1.202	0.1766
1435494_s_at	Dsp	Desmoplakin	109	16	247	47	6.723	4E–05	5.267	8E–06
1416271_at	Perp	PERP, TP53 apoptosis effector	849	455	1,436	557	1.864	6E–06	2.579	0.0002

M KO, male Cd82^−/−; M WT, male Cd82^+/+; F KO, female Cd82^−/−; F WT, female Cd82^+/+; KO/WT, ratio of Cd82^−/− to Cd82^+/+ signals.

All of them are altered by twofold in male MEFs except for Perp that is 1.86-fold. In female MEFs, Dsp, Perp are altered by twofold other than Kai1 down-regulation.