Table 5.

Developmental Toxicity Endpoints and Cyp1a Expression Patterns Mediated by AHR1a From Morpholino Knockdown Studies

Xenobiotic Ligand	Endpoints Mediated by Ligand x AHR1a	Results of AHR1a Knockdown	References
Chrysene	Vasculature Cyp1a expression	Reduction No change to epidermal Cyp1a expression	Incardona et al. (2005)
Pyrene	Liver abnormalities, pericardial edema, neural tube cell death	Reduction No change to dorsal curvature caused by pyrene exposure	Incardona et al. (2006)
Pyrene	Liver Cyp1a expression	Reduction No change to vascular Cyp1a expression	Incardona et al. (2006)
Leflunomide	Liver Cyp1a expression	Reduction	Goodale et al. (2012)
BkF + FL, PCB-126	Pericardial effusion Cyp1a activity	Greater pericardial effusion Increased activity	Garner et al. (2013)
Xanthone	Several developmental endpoints Liver Cyp1a expression	Attenuated malformations Reduction	Knecht et al. (2013)
mITP	Pericardial edema	Increased prevalence	Gerlach et al. (2014)
5-Nitroacenaphthalene	Pericardial and yolk sac edemas	Reduction	Chlebowski et al. (2017)
5-Nitroacenaphthalene, 9-nitrophenanthrene, and 7-nitrobenzo[k]fluoranthene	Liver Cyp1a expression	Reduction	Chlebowski et al. (2017)

Measured endpoints that were not altered upon AHR1a knockdown.