Table 6.

Developmental Toxicity Endpoints and Cyp1a Expression Patterns Mediated by AHR1b From Morpholino Knockdown Studies

Xenobiotic Ligand	Endpoints Mediated by Ligand x AHR1b	Results of AHR1b Knockdown	References
Leflunomide	— Vasculature Cyp1a expression	— Prevention	Goodale et al. (2012)
mITP	— Pericardial edema	— Reduction in prevalence of pericardial edema	Gerlach et al. (2014)
7-Nitrobenzo[k]fluoranthene	— Vasculature, skin, neuromast Cyp1a protein expression	— Slight reduction	Chlebowski et al. (2017)