Figure 3.
Comparison of gene expression and methylation changes from RNA-seq and DNA methyl-seq analyses between vehicle-treated Nkx2-5-positive cells and ES cells (A), and Nkx2-5-positive cells treated with TCDD for 24 (B), 72 (C), and 96 (D) h. type, cell type; methylation, mean methylation ratio; direction, direction of methylation change; expression, expression in rpkm; −log10(cor_p), correlation significance; location, genomic location; dist_tss, distance from transcription start site (TSS). Each experimental group had 2 biological replicates. Significance of correlation between DNA methylation and gene expression changes was measured by Pearson’s coefficient test, with threshold of significance at −log10 p ≥ 1.301.