Figure 4.

Direction of methylation and gene expression changes among the 111 targets in which differential methylation and gene expression are significantly correlated in all genomic regions (A), introns (B), coding regions (C), and promoters (D). Hypo + up, hypomethylated and upregulated gene expression; Hypo + down, hypormethylated and downegulated gene expression; Hyper + up, hypermethylated and upregulated gene expression; Hyper + down, hypermethylated and downregulated gene expression. Each experimental group had 2 biological replicates.