Table 1.

Absolute empiric recurrence risks for selected psychiatric disorders

	Schizophrenia	Bipolar disorder	Major depressive disorder
General population	1%	0.8%–1.6%	2%–23% (female) 1%–15% (male)
Affected parent, for same diagnosis	5%–13%	6%–15%	7%–26%
Affected parent, for either schizophrenia, bipolar, or depression	27% for offspring age 20 or older	27% for offspring age 20 or older	48% for offspring age 20 or older
Affected parent, for any diagnosed mental disorder	45% for offspring age 20 or older	58% for offspring age 20 or older	65% for offspring age 20 or older
Affected sibling	9%–16%	5%–20%	5%–30%
Affected second-degree relative (pooled)	2%–8%	5%	—
Risks for additional mental disorders (not comprehensive)	Schizoaffective disorder, personality disorders, bipolar disorder, major depression, substance use	Major depression, substance use, schizophrenia, schizoaffective disorder, anxiety disorder, ADHD	Anxiety disorders, substance use, disruptive disorders, dysthymia, ADHD

Contents of table adapted from Peay et al. 2017 and Rasic et al. 2014.

(FDRR) First-degree relative recurrence risk, (ADHD) attention deficit hyperactivity disorder.