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. 2020 Dec 1;34(23-24):1637–1649. doi: 10.1101/gad.341602.120

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© 2020 Bloom and Schimenti; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — PGCs lack a G1 DNA damage-responsive cell cycle checkpoint at E11.5, but E13.5 male germ cells acquire it at E13.5. (A) Representative cell cycle profiles of control and treated primordial germ cells. Percentage of cells in the indicated cell cycle stages are graphed, representing three experimental replicates. (B) Significantly enriched gene ontology terms among up-regulated genes in response to irradiation at E11.5. (C) Representative cell cycle profiles of E13.5 male germ cells. (IR) Ionizing radiation.