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. 2020 Dec 1;34(23-24):1637–1649. doi: 10.1101/gad.341602.120

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© 2020 Bloom and Schimenti; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Radiation exposure at E13.5 causes down-regulation of piRNA metabolism and derepression of transposons in male germ cells. (A) Significantly enriched GO terms among genes down-regulated in response to irradiation of E13.5 male germ cells. (B) Expression of piRNA metabolic process genes in control and irradiated E13.5 male germ cells. (C) Heat map of differentially expressed transposons between control and irradiated samples with an adjusted P-value <0.05. (D) Percentage of total mapped reads in control and irradiated samples that belong to piRNAs. (E) Classification of transposon-derived small RNAs. (F) Size distribution of small RNAs. (G) Fold change in piRNA expression in response to IR from small-RNA sequencing. The majority of the piRNAs (shown in teal) are not significantly up-regulated in response to IR. (MC) Male no IR, (MIR) male IR-treated).