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. 2020 Dec 1;34(23-24):1637–1649. doi: 10.1101/gad.341602.120

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© 2020 Bloom and Schimenti; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Irradiation exposure at E13.5 leads to premature retinoic acid (RA) signaling and meiotic entry disruption in female germ cells. (A) Expression of pluripotency-associated genes in control and irradiated E13.5 female germ cells. (B) Expression of RA-responsive genes in control and irradiated E13.5 female germ cells. (C) Expression of genes associated with spatial development of the fetal ovary in control and irradiated samples. The heat map is comprised of genes up-regulated in response to RA exposure; pink indicates higher expression, and green indicates lower expression (reference data set used for comparison from Soh et al. 2015). (D) t-SNE plot representing the similarity between the control and irradiated samples compared with Stra8^−/− from Soh et al. (2015). (FC) Female no IR, (FIR) female irradiated.