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. 2020 Dec 1;34(23-24):1637–1649. doi: 10.1101/gad.341602.120

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© 2020 Bloom and Schimenti; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Variant detection in genetically rescued germ cells reveals an alteration mutational profile compared with controls. (A) Distribution of total variants with respect to genotype. (B) Point mutation frequency shown as a percentage of the total number of variants identified in each cell. (Kruskal-Wallis test, q = 0.09 between p21^−/− and Fancm^−/− p21^−/−). (C) Insertion and deletion (InDel) mutation frequency shown as a percentage of the total number of variants identified in each cell. (Kruskal-Wallis test, q = 0.02 between p21^−/− and Fancm^−/− p21^−/−) (D) Complex variant frequency shown as a percentage of the total number of variants identified in each cell. (Kruskal-Wallis test, q = 0.04 between wild type and Fancm^−/− p21^−/−). (E) Examples of two complex mutations from Fancm^−/− p21^−/− spermatids. Shown are IGV screen shots.