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Model for DUSP11-mediated regulation of RIG-I signaling. The RNA triphosphatase DUSP11 dephosphorylates endogenous host and exogenous viral 5′-triphosphate RNAs and reduces the sensitivity of the RIG-I signaling response to these RNAs. The higher proportion of 5′-triphosphate RNAs in the absence of DUSP11 results in aberrant RIG-I sensing and increased interferon signaling.
