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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Cell. 2018 Oct 4;175(2):327–345. doi: 10.1016/j.cell.2018.09.021

Figure 3. Position-control genes are constitutively and regionally expressed in planarian muscle to control adult body plan maintenance and regeneration.

Figure 3.

A. Regeneration-patterning phenotypes. Left, trunk fragments regenerating heads and tails. Inhibition of Wnt pathway genes results in regeneration of posterior-facing heads. Inhibition of negative Wnt pathway regulators leads to regeneration of anterior-facing tails. Right, Bmp pathway inhibition leads to dorsal appearance of ventral attributes. B. PCG expression domains. Anterior, up. Data from (Scimone et al., 2016). C. Cartoon map of PCG transcription domains on the AP axis. Blue, Wnt-signaling related; Orange, FGFRL genes; Red, Hox genes; Purple, anterior transcription factors; Grey, unknown molecular function. Bottom: posterior-to-anterior gradient of β-catenin-1 protein level. D. Cartoon of PCG expression domains on the DV/ML axes. Bmp signaling is active dorsally and wnt5 - slit mutual inhibition mediates ML pattern.