Multispectral optoacoustic tomographic (MSOT) images from different commercially available optoacoustic (OA) medical imaging systems. Images were acquired noninvasively from patients with breast cancer (MSOT Acuity [iThera Medical] and Imagio [Seno Medical]) or from excised lymph nodes in patients with melanoma (Vevo LAZR [VisualSonics]). Each set of images exhibits US imaging, OA imaging, and the overlay of the two modalities. Adapted, with permission, from references 4 (MSOT Acuity), 9 (Imagio), and 10 (Vevo LAZR).