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. 2020 Nov 12;10:597743. doi: 10.3389/fonc.2020.597743

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Copyright © 2020 Coelho, Fernandes, Boccacino, Souza, Melo-Escobar, Alves, Prado, Iglesia, Cangiano, Mazzaro and Lopes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of signaling pathways involved with WNT/β-catenin, autophagy and epithelial-to-mesenchymal transition (EMT) in glioblastoma (GBM). The major players of the highlighted processes are grouped by a colour code, which differentiates microautophagy (mA, light blue), chaperone-mediated autophagy (CMA, purple), macroautophagy (MA, green), EMT (orange) and some metabolic processes (pink). AMPK, AMP Kinase; DKK, Dickkopf; DVL2, dishevelled 2; FOXM1, forkhead box protein M1; HIF1a, hypoxia-inducible factor 1a; LAMP2A KO, knockout of LAMP2A protein; LEF1, lymphoid enhancer factor 1; mTOR, mammalian target of rapamycin; PRMT, protein arginine methyltransferase; TCF1, T-cell factor 1; TMZ, temozolomide.