Figure 2.

Clinical disease signs in African green monkeys after infection with small particle aerosol MERS-CoV. A, B) Respiratory rates were observed twice daily for all groups and recorded. Statistically significant differences on the graph reflects analysis comparing respiratory rates between the 10³ and 10⁵ PFU dose groups. C, D) Clinical scores incorporated signs of MERS-CoV infection, based in part on observations of responsiveness, respiratory function (other than respiratory rate), lymphadenopathy, and dehydration. Differences between respiratory rate and clinical score groups were determined by using 1-way analysis of variance (Tukey’s multiple comparison test; *p<0.05, **p<0.01, ***p<0.001). MERS-CoV, Middle East respiratory syndrome coronavirus.