Table 1. Findings from physical examination, laboratory results, treatment regimens for 3 dogs infected with a novel Rickettsia species, United States*.

Examination and treatment	Case 1	Case 2	Case 3
Physical examination	Febrile (39.8°C); lethargy; +/− hepatomegaly	Febrile (40.1°C); lethargy; dehydration; joint effusion (elbow, carpus, and tarsus); arthropathy; shifting leg lameness	Febrile (39.8°C); lethargy; abdominal pain
CBC	Platelets 141 × 103 cells/µL (RI 200–500 × 103 cells/µL)	Platelets 139 × 103 cells/µL (RI 170–400 × 103 cells/µL)	Platelets 60 × 103 cells/µL (RI 125–500 × 103 cells/µL); Hct 35.2% (RI 36%–55%); 2 d later platelets 25 × 103 cells/µL and Hct 26.8%
SBP	Globulins 4.5 g/dL (RI 2.1–4.4 g/dL); ALP 177 U/L (RI 11–140 U/L); glucose 73 mg/dL (RI 75–125 mg/dL); sodium 136.5 mmol/L (RI 143–153 mmol/L)	Albumin 2.2 g/dL (RI 2.7–4.4 g/dL); ALT 1,158 U/L (RI 12–118 U/L); ALP 1,702 U/L (RI 5–131 U/L); cholesterol 352 mg/dL (RI 92–324 mg/dL); calcium 8.4 mg/dL (RI 8.9–11.4 mg/dL)	Albumin 1.0 mg/dL (RI 2.5–4.3 mg/dL); calcium 8.4 mg/dL (RI 8.9–11.4 mg/dL); BUN 35 (35, RI 7–28 mg/dL)
Urinalysis	USG 1.007	Microalbuminuria 3.1 (RI <2.5 mg/dL)	USG 1.033; 3+ proteinuria; UPC 14.7 (RI 0.00–1.00)
Treatment regimen	Doxycycline (6 mg/kg every 12 h for 21 d)	Doxycycline (7 mg/kg every 12h for 28 d); prednisone (1 mg/kg every 12 h for 9 mo with gradual taper); omeprazole (1.4 mg/kg every 12h for 9 mo); ondansetron (0.5 mg/kg every 12h for 15 d); and metronidazole (17 mg/kg every 12 h for 15 d)	Doxycycline (7.5 mg/kg q12 h for 40 d); prednisone (1 mg/kg every 12 h for 14 d, then 0.5mg/kg every 12 h for 6 d, then every 24 h for 22 d until death), mycophenolate (12.5 mg/kg every 12 h for 22 d until death)

*ALP, alkaline phosphatase activity; ALT, alanine amino transferase activity; BUN, blood urea nitrogen; CBC, complete blood count; Hct, hematocrit; RI, reference interval; SBP, serum biochemistry panel; UA, urinalysis; UPC, urine protein/creatinine ratio; USG, urine specific gravity.